Publications
Publications
2024
- T. Dayarathna, A.D. Roseborough, J. Gomes, R. Khazaee, C.R.A Silveira, K. Borron, S. Yu, K. Coleman, S. Jesso, E. Finger, P. MacDonald, M. Borrie, J. Wells, R. Bartha, G. Zou, S.N. Whitehead, H.S. Leong, and S.H. Pasternak. Nanoscale flow cytometry-based quantification of blood-based extracellular vesicle biomarkers distinguishes MCI and Alzheimer’s disease. Alzheimers Dement. 2024 Jul 3;10.1002/alz.14087.
- N. Ollen-Bittle, S. Pejhan, S.H. Pasternak, C.D. Keene, Q. Zhang, and S.N. Whitehead. Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease. Acta Neuropathol. 2024 Jun 19;147:105.
2023
- N. Ollen-Bittle, A.D. Roseborough, W. Wang, J.D. Wu, and S.N. Whitehead. Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury. Neural Regen. Res. 2023 Dec;19:2119–2131.
- A.D. Roseborough, N. Ollen-Bittle, and S.N. Whitehead. Using microglia-derived extracellular vesicles to capture diversity of microglial activation phenotypes following neurological injury. Neural Regen. Res. 2023 Dec;19:1633–1634.
- S.J Myers, V. Agapova, S.V. Patel, S.H Hayes, L.A. Sposato, B.L. Allman, and S.N. Whitehead. Acute minocycline treatment inhibits microglia activation, reduces infarct volume, and has domain-specific effects on post-ischemic stroke cognition in rats. Behav Brain Res. 2023 Sept 22;455:114680.
- N. Ollen-Bittle, C.A. Lowry, K.E. Donovan, R.D. Andrew, and S.N. Whitehead. Validating MALDI-IMS feasibility in ex vivo brain slices. J. Am. Soc. Mass Spectrom. 2023 Jul 20;34:1685–1691.
- A.D. Roseborough, S.J. Myers, R. Khazaee, Y. Zhu, L. Zhao, E. Iorio, F.M. Elahi, S.H. Pasternak, and S.N. Whitehead. Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model. J. Neuroinflammation. 2023 Jan 31;20.
- A.D. Roseborough, Y. Zhu, L. Zhao, S.R. Laviolette, S.H. Pasternak, and S.N. Whitehead. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implication for blood-brain barrier dysfunction. Neurobiol. Dis. 2023 Jan 13; 177:106001.
- S.J. Myers, V. Agapova, S.V. Patel, S.H. Hayes, L.A. Sposato, B.L. Allman, and S.N. Whitehead. Acute minocycline treatment inhibits microglia activation, reduces infarct volume, and has domain-specific effects on post-ischemic stroke cognition in rats. Behav Brain Res. 2023 Oct 18; 455:114680.
14) N. Ollen-Bittle, C.A. Lowry, K.E. Donovan, R.D. Andrew, and S.N. Whitehead. Validating MALDI-IMS feasibility in ex vivo brain slices. J Am Soc Mass Spectrom. 2023 Aug 2;34(8):1685-1691.
15) A.D. Roseborough, S.J. Myers, R. Khazee, Y. Zhu, L. Zhao, E. Iorio, F.M. Elahi, S.H. Pasternak, and S.N. Whitehead. Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model. J Neuroinflammation. 2023 Jan 31;20(1):20.
16) A.D. Roseborough, Y. Zhu, L. Zhao, S.R. Laviolette, S.H. Pasternak, and S.N. Whitehead. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: implications for blood brain barrier dysfunction. Neurobiol Dis. 2023 Feb;177:106001.
17) M. De Felice, C. Chen, M. Rodriguez-Ruiz, H.J. Szkudlarek, M. Lam, S. Sert, S.N. Whitehead, K.K.C. Yeung, W.J. Rushlow, and S.R. Laviolette. Adolescent 9-Tetrahydrocannabionol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions. Neuropsychopharmacology. 2023 Feb;48(3):540-551.
18) K.T. Murphy, J. Camenzuli, S.J. Myers, S.N. Whitehead, N. Rajakumar, and J. Melling. Assessment of executive function in a rodent model of type 1 diabetes. Behav Brain Res. 2023 Feb 2;437:114130.
2022
- S.V. Patel, C.M. DeCarlo, S.A. Book, A.L. Schormans, S.N. Whitehead, B.L. Allman, and S.H. Hayes. Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function. Front. Neurosci. 2022;16.
- N. Ollen-Bittle, A.D. Roseborough, W. Wang, J.D. Wu, and S.N. Whitehead. Mechanisms and biomarker potential of extracellular vesicles in stroke. Biology (Basel). 2022 Aug 18;11(8):1231.
- S.J. Myers, A.J. Ruiz, L. Sposato, and S.N. Whitehead. Cognitive impairment following atrial cardiopathy. Front. Aging Neurosci. 2022;14:914360.
- A. Levit, V. Hachinksi, and S.N. Whitehead. Developments in NEW triad research. Aging. 2022. May 4;14.
- P.M. Kawalewska, J.E. Piazza, S. L. Milkovich, R.J. Sove, L. Wang, S.N. Whitehead, and C.G. Ellis. Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in rat fecal peritonitis model. Sci Rep. 2022 Apr 15;12(1):6339.
- A.D. Roseborough, L. Saad, M. Goodman, L. Cipriano, V.C. Hachinski, and S.N. Whitehead. White matter hyperintensities and longitudinal cognitive decline: A meta-analysis and systematic review of baseline WMH and cognitive outcomes across diagnostic categories. Alzheimers Dement. 2022 Mar 23.
- J.L. MacKenzie, N. Ivanova, H.J. Nell, C.R. Giordano, S.R. Terlecky, C. Agca, Y. Agca, P.A. Walton, S.N. Whitehead, and D.F. Cechetto. Microglia inflammation and cognitive dysfunction in comorbid rat models of striatal ischemic stroke and Alzheimer’s disease: effects of antioxidant catalase-SKL on behavioural and cellular pathology. Neuroscience. 2022 Apr 1;487:47-65.
- S.N. Whitehead, A. Bruno, J. Burns, S.T. Carmichael, A.Csiszar, J.D. Edwards, F. Elahi, G. Faraco, D.B. Gould, D.R. Gustafson, V. Hachinski, F.A. Sorond, A.Y. Shih, K.H. Tse, Z. Ungvari, D.M. Wilcock, K.L. Zuloaga, and F.C. Barone. Expanding the horizon of research in the pathogenesis of white matter disease: Proceedings of the 2021 annual workshop of the Albert Research Institute for White Matter and Cognition. Geroscience. 2022 Feb;44(1):25-37.
- A.D. Roseborough, V.M. Jaremek, and S.N. Whitehead. White matter-associate microglia (WAMs) represent an important link between aging, white matter disease and microglia activity. Geroscience. 2022 Feb;44(1):63-65.
- A.D. Roseborough, Y. Jung, K. Nishimura, W. Pinsky, K. Langdon, R. Hammond, S. Pasternak, A. Khan, and S.N. Whitehead. Microvessel stenosis, fibrinogen deposition and microgliosis are associated with post-mortem MRI of periventricular infarcts in aging, cerebrovascular and Alzheimer’s disease. Brain Pathol. 2022 Jan;32(1):e13017.
2021
- A. Albofazl, V. Hachinski, A.H Aamodt, C. Alessi, S. Ali, S. Alladi, R. Andersen, K.K. Anderson, M.R. Azarpazhooh, C.L.A. Bassetti, M. Brainin, A. Brodtmann, A.M. Buchan, A. Charway-Felli, L.E. Cipriano, M. Endres, T.G. Evans, A. Federico, V.L. Feigin, J.M. Ferro, M. Freedman, S.J. Frisbee, V. Fuster, D. Ganten, J. Gilliland, J. Kimura, J. Kirton, L. Kuey, S.C.O. Martins, N. Mokhber, Y. Nilanont, A. Nucera, S. Oveisgharan, A.M. Owen, M. Owolabi, K.A. Rogers, G.A. Rouleau, R.L. Sacco, S.Stranges, S.N. Whitehead, P.J. Whitehouse, and P. Wilk. Brain Health: Key to health, productivity, and well-being. Alzheimers Dement. 2021 Sep 27
- D. Mohrle, W. Wang, S.N. Whitehead and S. Schmid. GABA-B receptor agonist R-Baclofen reverses altered auditory and filtering in the Cntnap2 knock-out rat. Front Integr Neurosci. 2021;15:710593.
- A. Levit, A. Gibson, O. Hough, Y. Jung, Y. Agca, C. Agca, V. Hachinski, B.L. Allman and S.N. Whitehead. Precocious white matter inflammation and behavioural inflexibility precede learning and memory impairment in the TgAPP21 rat. Mol Neurobiol. 2021 Oct;58(10):5014-5030.
- S. Hayes, Q. Liu,, S. Selvakumar, M. Haney, E. Batrakova, B. Allman, P. Walton, P.Kiser* and S.N. Whitehead*. Brain targeting and toxicological assessment of the extracellular vesicle-package antioxidant catalase-SKL following intranasal administration in mice. Neurotox Res. 2021 Oct;39(5):1418-1429. * Both authors contributed equally.
- C. Chen, S.R. Laviolette, S.N. Whitehead, J. Renaud, and K.K.C. Yeung. Imaging of neurotransmitters and small molecules in brain tissues using MALDI-MS assisted with zinc oxide nanoparticles. J Am Soc Mass Spectrom. 2021 Apr 7;32(4):1065-1079.
- Y. Dong, C. D’Mello, W. Pinsky, B.M Lozinski, D.K Kaushik, S. Ghorbani, D. Moezzi, D. Brown, F.C Melo, S. Zandee, T. Vo, A. Prat, S.N. Whitehead and V.W. Yong. Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia. neurodegeneration and are neutralized by microglia. Nature Neuroscience, 2021, Apr;24(4):489-503.
- W. Pinsky, A. Harris, A.D. Roseborough, W. Wang, K. Jurcic, A.R. Khan, K.K.C. Yeung, S.H. Pasternak, and S.N. Whitehead. Regional lipid expression abnormalities identified using MALDI-IMS correspond to MRI-defined white matter hyperintensities within post-mortem human brain tissue. Analytical Chemistry. 2021 Feb 2;93(4):2652-2659
2020
- N.U. Al-Khishman, Q. Qi, A.D. Roseborough, A. Levit, M.S. Fox, S.N. Whitehead* and J.D. Thiessen*. TPSO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat. Accepted, European Journal of Nuclear Medicine and Molecular Imaging Research 2020 Sep 29;10(1):113. * Both authors contributed equally.
- A.D. Roseborough, K.D. Langdon, R. Hammond, L.E. Cipriano, S. Pasternak, S.N. Whitehead* and A.R. Khan*. Post-mortem 7 Tesla MRI detection of white matter hyperintensities: A multidisciplinary voxel-wise comparison of imaging and histological correlates. Neuroimage Clin. 2020;27:102340. doi: 10.1016/j.nicl.2020.102340. Epub 2020 Jul 6.* Both authors contributed equally.
- A.D. Roseborough, V. Hachinski and S.N. Whitehead. White matter degeneration – a treatable target? JAMA Neurol. 2020 Apr 27
- A. Levit, S. Cheng, O. Hough, Y. Agca, C. Agca, V. Hachinski and S.N. Whitehead. Hypertension and pathogenic hAPP independently induce white matter astrocytosis and cognitive impairment in the rat. Front Aging Neurosci. 2020 Apr 15;12:82.
- M. Frietas-Andrade, J. Bechberger, J.S.H Wang, K.K.C Yeung, S.N. Whitehead, R.S Hansen, C.C. Naus. Danegaptide enhances astrocyte gap junction al coupling and reduces ischemic reperfusion brain injury in mice. Biomolecules. 2020 Feb 26;10(3):353
- W.X. Wang and S.N. Whitehead. Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain. Analyst. 2020 Apr 7;145(7):2473-2481.
- A. Levit, V. Hachinski and S.N. Whitehead. Executive dysfunction, white matter pathology, and neurovascular unit dysregulation: the shared triad of vascular cognitive impairment and Alzheimer’s disease. Geroscience. 2020 Apr;42(2):445-465.
- A. Harris, A. Roseborough, R. Mor, K.K.C. Yeung and S.N. Whitehead. Ganglioside detection from formalin fixed human brain tissue utilizing MALDI imaging mass spectrometry. J Am Soc Mass Spectrom. 2020 Mar 4;31(3):479-487.
- N. Ivanova, Q. Liu, C. Agca, Y. Agca, E.G. Noble, S.N. Whitehead and D.F. Cechetto. White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model. J Neuroinflammation. 2020 Jan 21;17(1):29
2019
- F. Sorond, S.N. Whitehead, K. Arai, D. Arnold, S.T. Carmichael, C. De Carli, M. Duering, M. Fornage, R.E. Flores-Obando, J. Graff-Radford, E. Hamel, D.C. Hess, M. Ihara, M.K. Jensen, H.S. Markus, A. Montagne, G. Rosenberg, A.Y. Shih, E. E. Smith, A. Thiel, K.H. Tse, D. Wilcock and F. Barone. Proceedings for the Albert Charitable Trust inaugural workshop on white matter and cognition in aging. Accepted, GeroScience – Journal of the American Aging Association, 2019.
- A. Harris, A. Roseborough, R. Mor, K.K.C. Yeung and S.N. Whitehead. Ganglioside detection from formalin fixed human brain tissue utilizing MALDI imaging mass spectrometry. Accepted, J Am Soc Mass Spectrom. 2019.
- N. Ivanova, C. Agca, Y. Agca, E.G. Noble, S.N. Whitehead and D.F. Cechetto. Comorbidity of Alzheimer’s disease and metabolic syndrome in the APP21 transgenic rat. Accepted, Journal of Neuroinflammation, 2019.
- V. Hachinski, K. Einhaupl, D. Ganten, S. Alladi, C. Brayne, B.C.M. Stephan, Z. Khachaturian, M. Sweeney, B. Zlokovic, Y. Iturria-Medina, C. Iadecola, N. Nishimura, C.B. Schaffer, S.N. Whitehead, S.E. Black, L. Ostergaard, J. Wardlaw, S. Greenberg, L. Friberg, B. Norrving, B. Rowe, Y. Joanette, W. Hacke, L. Kuller, M. Dichgans and M. Endres. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. Int J Stroke. 2019 Sep 22
- V.M. Jaremek, S.N. Whitehead and L.A. Sposato. Lateralization of the control of cardiovascular autonomic function and left atrial injury after selective right and left insular stroke. Int J Cardiol. 2019.
- V. Hachinski, K. Einhaupl, D. Ganten, S. Alladi, C. Brayne, B.C.M. Stephan, Z. Khachaturian, M. Sweeney, B. Zlokovic, Y. Iturria-Medina, C. Iadecola, N. Nishimura, C.B. Schaffer, S.N. Whitehead, S.E. Black, L. Ostergaard, J. Wardlaw, S. Greenberg, L. Friberg, B. Norrving, B. Rowe, Y. Joanette, W. Hacke, L. Kuller, M. Dichgans and M. Endres. Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimers Dement. 2019 Jul;15(7):961-984.
- B. Balint*, V. Jaremek*, V. Thorburn, M. Paquet, S.N. Whitehead* and L.A. Sposato*. Left atrial endothelial dysfunction, inflammation and fibrosis induced by selective insular cortex ischemic stroke in rats. Int J Cardiol. 2019 Jun 2. * Both authors contributed equally.
- B. Halvorsron, S.N. Whitehead, J. McGuire, R. Wiseman, and J. Frisbee. Endothelium-dependent impairments to cerebral vascular reactivity with type-II diabetes mellitus in the Goto-Kakizaki rat. Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R149-R159
- A. Levit, A.M. Regis, A. Gibson, O.H. Hough, S. Maheshawari, Y. Agca, C. Agca, V. Hachinski, B.L. Allman and S.N. Whitehead. Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease. Brain Behav Immun. 2019 Feb 15.
- C. Caughlin, J. Hepburn, Q. Liu, L. Wang, K.K.C Yeung, D.F. Cechetto and S.N. Whitehead. Chloroquine restores ganglioside homeostasis and improves pathological and behavioural outcomes post-stroke in the rat. Mol Neurobiol. 2019 May;56(5):3552-3562.
2018
- N. Weishaupt*, Q. Liu*, S. Shin, R. Singh, Y. Agca, C. Agca, V. Hachinski and S.N. Whitehead. APP21transgenic rats develop age-dependent cognitive impairment and microglia within white matter tracts. J Neuroinflammation. 2018 Aug 28;15(1):241. * Both authors contributed equally.
- L.A. Sposato, S. Fridman, S.N. Whitehead and R.D. Lopes. Linking stroke-induced heart injury and neurogenic atrial fibrillation: a hypothesis to be proven. J Electrocardiol. 2018 Feb 20.
- J.S.H Wang, M.F. Andrade, J. Bechberger, C. Naus, K.K.C. Yeung and S.N. Whitehead. MALDI-IMS of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke-reperfusion injury in the mouse. Rapid Commun Mass Spectrom. 2018 Jun 30;32(12):951-958.
- S. Caughlin, S. Maheshwari, Y. Agca, C. Agca, K.K.C. Yeung, D.F. Cechetto and S.N. Whitehead. Membrane-lipid homeostasis in a prodromal rat model of AD: Characteristic shifts in ganglioside abundance during aging detected using MALDI imaging mass spectrometry. Biochim Biophys Acta. 2018 Mar 13;1862(6):1327-1338.
- J.S.H. Wang, S.N. Whitehead* and K.K.C. Yeung*. Detection of amyloid beta oligomeric composition using matrix assisted laser desorption ionization mass spectrometry. J Am Soc Mass Spectrom. 2018 Apr;29(4):786-795. * Both authors contributed equally.
- J.R. Plemel, N.J. Michaels, N. Weishaupt, A.V. Caprariello, M.B. Keough, J.A Rogers, A. Yuseloglu, J. Lim, V.V. Patel, K.S. Rawji, S.K. Jensen, W. Teo, B. Heyne, S.N. Whitehead, P.K. Stys and V.W. Yong. Mechanisms of lysophosphatidylcholine-induced demyelination: a primary lipid disrupting myelinopathy. Glia. 2018 Feb;66(2):327-347.
2017
- H. Ibrahim, K. Jurcic, J.S. Wang, S.N. Whitehead and K.K. Yeung. 1,6-Diphenyl-1,3,5-hexatriene (DPH) as a novel matrix for MALDI MS imaging of fatty acids, phospholipids and sulfatides in brain tissues. Anal Chem. 2017 Dec 5;89(23):12828-12836.
- M. Paquet, J.O. Cerasuolo, V. Thorburn, S. Fridman, R. Alsubaie, R.D. Lopes, L.E. Cipriano, P. Salamone, C. W. James Melling, A.R. Khan, L. Sedeño, J. Fang, M. Drangova, M. Montero-Odasso, J. Mandzia, A.V. Khaw, J.M. Racosta, M.J. Paturel, L. Samoilov, D. Stirling, B. Balint, V. Jaremek, M.L. Koschinsky, M.B. Boffa, K. Summers, A. Ibañez, M. Mrkobrada, G. Saposnik, K. Kimpinski, S.N. Whitehead, and L.A. Sposato. The pathophysiology and risk of atrial fibrillation detected after ischemic stroke (PARADISE) study: A translational, integrated and transdisciplinary approach. J Stroke Cerebrovasc Dis. 2018 Mar;27(3):606-619.
- S. Caughlin, S. Maheshwari, N. Weishaupt, K.K.C. Yeung, D.F. Cechetto and S.N. Whitehead. Age-dependent and regional heterogeneity in the long-chain base of A-series gangliosides observed in the rat brain using MALDI imaging. Sci Rep. 2017 Nov 23;7(1):16135.
- A. Levit*, A.M. Regis*, J.R. Garabon, O. Seung, S.H. Desai, N. Rajakumar, V. Hachinski, Y. Agca, C. Agca, S.N. Whitehead* and B.L. Allman*. Novel analyses of behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression. Behav Brain Res. 2017 Aug 30; 333:267-275. * Both authors contributed equally.
- S. Caughlin, D.H Park, K.K.C Yeung, D.F. Cechetto and S.N. Whitehead. Sublimation of DAN matrix for the detection and visualization of gangliosides in rat brain tissue for MALDI imaging mass spectrometry. J Vis Exp. 2017 Mar 23;(121).
- L.A. Sposato, E.R. Vargas, P.M Riccio, J.B. Toledo, J.Q. Trojanowski, W.A. Kukull, L.E. Cipriano, A. Nucera, S.N. Whitehead and V.C. Hachinksi. Milder Alzheimer’s disease pathology in heart failure and atrial fibrillation. Alzheimer’s and Dementia, 2017 Jul;13(7):770-777
- H.J. Nell, J.L. Au, C.R. Giordano, S.R. Terlecky, P.A. Walton, S.N. Whitehead and D.F. Cechetto. The targeted antioxidant, catalase-SKL, reduces beta-amyloid toxicity in the rat brain. Brain Pathol. 2017 Jan;27(1):86-94.
2016
- S. Wong, D.F. Cechetto and S.N. Whitehead. Assessing the effects of acute amyloid beta oligomer exposure in the rat. Int. J. Mol. Sci. 2016, 17(9), 1390
- H. Park, L. Wang, P. Pittock, G.A. Lajoie and S.N. Whitehead. Increased expression of GM1 detected by electrospray mass spectrometry in rat primary embryonic cortical neurons exposed to glutamate toxicity. Anal Chem. 2016 Aug 2;88(15):7844-52
- H. Deibel*, N. Weishaupt*, A.M. Regis, N S. Hong, R.J. Keeley, RJ. Balog, C.M. Bye, S.M Himmler, S.N. Whitehead* and R. J. McDonald*. Subtle learning and momery impairment in an idiopathic rat model of Alzheimer’s disease utilizing cholinergic depletions and beta-amyloid. Brain Res. 2016 Sep 1;1646:12-24.* Authors contributed equally.
- L. Au, N. Weishaupt, H.J. Nell, S.N. Whitehead and D.F Cechetto. Motor assessment and hippocampal dependent spatial learning and reference assessment in a transgenic rat model of Alzheimer’s disease with stroke. J Vis Exp. 2016 Mar 22;(109)
- Weishaupt, A. Zhang, R. Deziel, A. Tasker and S.N. Whitehead. Prefrontal ischemia in the rat leads to secondary damage and inflammation in remote grey and white matter regions. Front Neurosci. 2016 Mar 2;10:8
- Xu, F. Bihari, S.N. Whitehead, E. Wong, S. Schmid and M.O. Hebb. Intratumoral modulation therapy induces apoptosis and facilitates temozolomide and gene therapy in glioblastoma. Anticancer Res. 2016 Jan; 36(1):71-
2015
- Weishaupt, S. Caughlin, K.K.C. Yeung and S.N. Whitehead. Differential anatomical expression of ganglioside GM1 species containing d18:1 or d20:1 sphingosine detected by MALDI Imaging Mass Spectrometry in mature rat brain. Front Neuroanat. 2015 Dec 1;9:155.
- Weishaupt, P. Riccio, T. Dobbs, V.C. Hachinski and S.N. Whitehead. Characterization of behaviour and remote degenerative processes following thalamic stroke. Int J Mol Sci. 2015 Jun 17;16(6):13921-36.
- Caughlin, J. Hepburn, D.H. Park, K. Jurcic, K. Yeung, D.F. Cechetto and S.N. Whitehead. Increased expression of simple gangliosides species GM2 and GM3 detected by MALDI imaging mass spectrometry in a combined rat model of Abeta toxicity and stroke. PLoS One. 2015 Jun 18;10(6):e0130364.
- Amtul, S.N. Whitehead, R. Keeley, J. Bechberger, A. Fisher, R. McDonald, C. Naus, D. Munoz and D.F. Cechetto. Co-morbid rat model of ischemia and beta-amyloid toxicity: Striatal and cortical degeneration. Brain Pathol. 2015 Jan;25(1):24-32.
2010 - 2014
- H.J. Nell, S.N. Whitehead and D.F. Cechetto. Age dependent effect of β-amyloid toxicity on basal forebrain cholinergic neurons and inflammation in the rat brain. Brain Pathol. 2014 Sep 3.
- A. Thiel, D.F. Cechetto, V.C Hachinski and S.N. Whitehead. Amyloid burden, neuroinflammation and links to post-stroke cognitive impairment. Stroke. 2014 Sep;45(9):2825-9.
- S. Gangaraju, K. Sultan, S.N Whitehead, L Nilchi, J. Slinn, X. Li, and S.T Hou. Cerebral endothelial expression of Robo1 affects brain infiltration of polymorphonuclear neutrophils during mouse stroke recovery. Neurobiol Dis. 2013 Mar 5;54C:24-31
- P. Soros, S.N. Whitehead, J.D. Spence and V.C. Hachinski. Antihypertensive treatment can prevent stroke and cognitive decline. Nat Rev Neurol. 2013 Mar;9(3):174-8.
- S.N. Whitehead, S. Gangaraju, A. Aylsworth and S.T. Hou. Membrane raft disruption results in neuritic retraction prior to neuronal death in cortical neurons. Biosci Trends. 2012 Aug;6(4):183-91
- S.N. Whitehead, K.H.N Chan, S. Gangaraju, J. Slinn, J. Li and S.T. Hou. Imaging Mass Spectrometry Detection of Gangliosides Species Within the Mouse Brain Following Transient Focal Cerebral Ischemia. PLoS One. 2011;6(6):e20808. Epub 2011 Jun 8
- S.N. Whitehead, E. Massoni, G. Cheng, V. Hachinski, M. Cimino, W. Balduini and D. F. Cechetto. Brain Res. 2010 Dec 17;1366:246-56. Epub 2010 Oct 8.
- S.N. Whitehead, S. Gangaraju, J. Slinn and S.T. Hou. Transient and bilateral increase in Neuropilin-1, Fer kinase and collapsin response mediator proteins within membrane rafts following unilateral occlusion of the middle cerebral artery in mouse. Brain Res. 2010 Jul 16;1344:209-16.
- S.X. Jiang, S.N. Whitehead, A. Aylsworth, J. Slinn, B. Zurakouski, K. Chan, J. Li and S.T. Hou. Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin3A-induced death of cortical neurons. J Biol Chem. 2010 Mar 26;285(13):9908-18
- M.A. Cortex, C. Li, S.N. Whitehead, L.J. Huan, S.A.L Bennett, C. Snead and C.E. Bear. Disruption of CLC-2 expression leads to neurodegeneration in aging mice. Neuroscience. 2010 Apr 28;167(1):154-62
2005 - 2009
- S.D Ryan, S.N. Whitehead, W. Hou, L. Swayne, M. Ethier, A.J.G Bourgeois, T.C. Moffat, J. Rashidian J, D. Qu, P.E. Fraser, D. Figeys, D.S. Park and S.A.L. Bennett. Aberrant lipid metabolism compromises neuronal vulnerability in Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Nov 19.
- J.C. Smith, W. Hou, S.N. Whitehead, M. Ethier, S.A.L. Bennett and D. Figeys. Real-time sequencing of glycerophospholipids in vitro and in vivo using LC-MS3. Rapid Comm. In Rapid Commun Mass Spectrom. 2008 Nov;22(22):3579-87.
- D.F. Cechetto, V.C. Hachinski and S.N. Whitehead. Vascular risk factors and Alzheimer’s disease. Expert Rev Neurother. 2008 May;8(5):743-50.
- S. Wislet-Gendebien, N. Visanji, S.N. Whitehead, D. Marsilio, W. Hou, D. Figeys, P.E. Fraser, S.A.L. Bennett, and A. Tandon. Differential regulation of wild-type and mutant α-synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci. 2008 Sep 22;9:92
- S.N. Whitehead, G. Cheng, V. Hachinski and D.F. Cechetto. Progressive increase in infarct size, neuroinflammation and cognitive deficits in the presence of high levels of amyloid. Stroke. 2007 Dec;38(12):3245-50.
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