Publications

Publications

2024

  • T. Dayarathna, A.D. Roseborough, J. Gomes, R. Khazaee, C.R.A Silveira, K. Borron, S. Yu, K. Coleman, S. Jesso, E. Finger, P. MacDonald, M. Borrie, J. Wells, R. Bartha, G. Zou, S.N. Whitehead, H.S. Leong, and S.H. Pasternak. Nanoscale flow cytometry-based quantification of blood-based extracellular vesicle biomarkers distinguishes MCI and Alzheimer’s disease. Alzheimers Dement. 2024 Jul 3;10.1002/alz.14087.
  • N. Ollen-Bittle, S. Pejhan, S.H. Pasternak, C.D. Keene, Q. Zhang, and S.N. Whitehead. Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease. Acta Neuropathol. 2024 Jun 19;147:105.

2023

  • N. Ollen-Bittle, A.D. Roseborough, W. Wang, J.D. Wu, and S.N. Whitehead. Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury. Neural Regen. Res. 2023 Dec;19:2119–2131.
  • A.D. Roseborough, N. Ollen-Bittle, and S.N. Whitehead. Using microglia-derived extracellular vesicles to capture diversity of microglial activation phenotypes following neurological injury. Neural Regen. Res. 2023 Dec;19:1633–1634.
  • S.J Myers, V. Agapova, S.V. Patel, S.H Hayes, L.A. Sposato, B.L. Allman, and S.N. Whitehead. Acute minocycline treatment inhibits microglia activation, reduces infarct volume, and has domain-specific effects on post-ischemic stroke cognition in rats. Behav Brain Res. 2023 Sept 22;455:114680.
  • N. Ollen-Bittle, C.A. Lowry, K.E. Donovan, R.D. Andrew, and S.N. Whitehead. Validating MALDI-IMS feasibility in ex vivo brain slices. J. Am. Soc. Mass Spectrom. 2023 Jul 20;34:1685–1691.
  • A.D. Roseborough, S.J. Myers, R. Khazaee, Y. Zhu, L. Zhao, E. Iorio, F.M. Elahi, S.H. Pasternak, and S.N. Whitehead. Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model. J. Neuroinflammation. 2023 Jan 31;20.
  • A.D. Roseborough, Y. Zhu, L. Zhao, S.R. Laviolette, S.H. Pasternak, and S.N. Whitehead. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implication for blood-brain barrier dysfunction. Neurobiol. Dis. 2023 Jan 13; 177:106001.
  • S.J. Myers, V. Agapova, S.V. Patel, S.H. Hayes, L.A. Sposato, B.L. Allman, and S.N. Whitehead. Acute minocycline treatment inhibits microglia activation, reduces infarct volume, and has domain-specific effects on post-ischemic stroke cognition in rats. Behav Brain Res. 2023 Oct 18; 455:114680.
    14) N. Ollen-Bittle, C.A. Lowry, K.E. Donovan, R.D. Andrew, and S.N. Whitehead. Validating MALDI-IMS feasibility in ex vivo brain slices. J Am Soc Mass Spectrom. 2023 Aug 2;34(8):1685-1691.
    15) A.D. Roseborough, S.J. Myers, R. Khazee, Y. Zhu, L. Zhao, E. Iorio, F.M. Elahi, S.H. Pasternak, and S.N. Whitehead. Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model. J Neuroinflammation. 2023 Jan 31;20(1):20.
    16) A.D. Roseborough, Y. Zhu, L. Zhao, S.R. Laviolette, S.H. Pasternak, and S.N. Whitehead. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: implications for blood brain barrier dysfunction. Neurobiol Dis. 2023 Feb;177:106001.
    17) M. De Felice, C. Chen, M. Rodriguez-Ruiz, H.J. Szkudlarek, M. Lam, S. Sert, S.N. Whitehead, K.K.C. Yeung, W.J. Rushlow, and S.R. Laviolette. Adolescent 9-Tetrahydrocannabionol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions. Neuropsychopharmacology. 2023 Feb;48(3):540-551.
    18) K.T. Murphy, J. Camenzuli, S.J. Myers, S.N. Whitehead, N. Rajakumar, and J. Melling. Assessment of executive function in a rodent model of type 1 diabetes. Behav Brain Res. 2023 Feb 2;437:114130.

2022

  • S.V. Patel, C.M. DeCarlo, S.A. Book, A.L. Schormans, S.N. Whitehead, B.L. Allman, and S.H. Hayes. Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function. Front. Neurosci. 2022;16.
  • N. Ollen-Bittle, A.D. Roseborough, W. Wang, J.D. Wu, and S.N. Whitehead. Mechanisms and biomarker potential of extracellular vesicles in stroke. Biology (Basel). 2022 Aug 18;11(8):1231.
  • S.J. Myers, A.J. Ruiz, L. Sposato, and S.N. Whitehead. Cognitive impairment following atrial cardiopathy. Front. Aging Neurosci. 2022;14:914360.
  • A. Levit, V. Hachinksi, and S.N. Whitehead. Developments in NEW triad research. Aging. 2022. May 4;14.
  • P.M. Kawalewska, J.E. Piazza, S. L. Milkovich, R.J. Sove, L. Wang, S.N. Whitehead, and C.G. Ellis. Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in rat fecal peritonitis model. Sci Rep. 2022 Apr 15;12(1):6339.
  • A.D. Roseborough, L. Saad, M. Goodman, L. Cipriano, V.C. Hachinski, and S.N. Whitehead. White matter hyperintensities and longitudinal cognitive decline: A meta-analysis and systematic review of baseline WMH and cognitive outcomes across diagnostic categories. Alzheimers Dement. 2022 Mar 23.
  • J.L. MacKenzie, N. Ivanova, H.J. Nell, C.R. Giordano, S.R. Terlecky, C. Agca, Y. Agca, P.A. Walton, S.N. Whitehead, and D.F. Cechetto. Microglia inflammation and cognitive dysfunction in comorbid rat models of striatal ischemic stroke and Alzheimer’s disease: effects of antioxidant catalase-SKL on behavioural and cellular pathology. Neuroscience. 2022 Apr 1;487:47-65.
  • S.N. Whitehead, A. Bruno, J. Burns, S.T. Carmichael, A.Csiszar, J.D. Edwards, F. Elahi, G. Faraco, D.B. Gould, D.R. Gustafson, V. Hachinski, F.A. Sorond, A.Y. Shih, K.H. Tse, Z. Ungvari, D.M. Wilcock, K.L. Zuloaga, and F.C. Barone. Expanding the horizon of research in the pathogenesis of white matter disease: Proceedings of the 2021 annual workshop of the Albert Research Institute for White Matter and Cognition. Geroscience. 2022 Feb;44(1):25-37.
  • A.D. Roseborough, V.M. Jaremek, and S.N. Whitehead. White matter-associate microglia (WAMs) represent an important link between aging, white matter disease and microglia activity. Geroscience. 2022 Feb;44(1):63-65.
  • A.D. Roseborough, Y. Jung, K. Nishimura, W. Pinsky, K. Langdon, R. Hammond, S. Pasternak, A. Khan, and S.N. Whitehead. Microvessel stenosis, fibrinogen deposition and microgliosis are associated with post-mortem MRI of periventricular infarcts in aging, cerebrovascular and Alzheimer’s disease. Brain Pathol. 2022 Jan;32(1):e13017.

2021

  • A. Albofazl, V. Hachinski, A.H Aamodt, C. Alessi, S. Ali, S. Alladi, R. Andersen, K.K. Anderson, M.R. Azarpazhooh, C.L.A. Bassetti, M. Brainin, A. Brodtmann, A.M. Buchan, A. Charway-Felli, L.E. Cipriano, M. Endres, T.G. Evans, A. Federico, V.L. Feigin, J.M. Ferro, M. Freedman, S.J. Frisbee, V. Fuster, D. Ganten, J. Gilliland, J. Kimura, J. Kirton, L. Kuey, S.C.O. Martins, N. Mokhber, Y. Nilanont, A. Nucera, S. Oveisgharan, A.M. Owen, M. Owolabi, K.A. Rogers, G.A. Rouleau, R.L. Sacco, S.Stranges, S.N. Whitehead, P.J. Whitehouse, and P. Wilk. Brain Health: Key to health, productivity, and well-being. Alzheimers Dement. 2021 Sep 27
  • D. Mohrle, W. Wang, S.N. Whitehead and S. Schmid. GABA-B receptor agonist R-Baclofen reverses altered auditory and filtering in the Cntnap2 knock-out rat. Front Integr Neurosci. 2021;15:710593.
  • A. Levit, A. Gibson, O. Hough, Y. Jung, Y. Agca, C. Agca, V. Hachinski, B.L. Allman and S.N. Whitehead. Precocious white matter inflammation and behavioural inflexibility precede learning and memory impairment in the TgAPP21 rat. Mol Neurobiol. 2021 Oct;58(10):5014-5030.
  • S. Hayes, Q. Liu,, S. Selvakumar, M. Haney, E. Batrakova, B. Allman, P. Walton, P.Kiser* and S.N. Whitehead*. Brain targeting and toxicological assessment of the extracellular vesicle-package antioxidant catalase-SKL following intranasal administration in mice. Neurotox Res. 2021 Oct;39(5):1418-1429. * Both authors contributed equally.
  • C. Chen, S.R. Laviolette, S.N. Whitehead, J. Renaud, and K.K.C. Yeung. Imaging of neurotransmitters and small molecules in brain tissues using MALDI-MS assisted with zinc oxide nanoparticles.  J Am Soc Mass Spectrom. 2021 Apr 7;32(4):1065-1079.
  • Y. Dong, C. D’Mello, W. Pinsky, B.M Lozinski, D.K Kaushik, S. Ghorbani, D. Moezzi, D. Brown, F.C Melo, S. Zandee, T. Vo, A. Prat, S.N. Whitehead and V.W. Yong. Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia. neurodegeneration and are neutralized by microglia.  Nature Neuroscience, 2021, Apr;24(4):489-503.
  • W. Pinsky, A. Harris, A.D. Roseborough, W. Wang, K. Jurcic, A.R. Khan, K.K.C. Yeung, S.H. Pasternak, and S.N. Whitehead. Regional lipid expression abnormalities identified using MALDI-IMS correspond to MRI-defined white matter hyperintensities within post-mortem human brain tissue. Analytical Chemistry. 2021 Feb 2;93(4):2652-2659

2020

  • N.U. Al-Khishman, Q. Qi, A.D. Roseborough, A. Levit, M.S. Fox, S.N. Whitehead* and J.D. Thiessen*. TPSO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat.  Accepted, European Journal of Nuclear Medicine and Molecular Imaging Research 2020 Sep 29;10(1):113. * Both authors contributed equally.
  • A.D. Roseborough, K.D. Langdon, R. Hammond, L.E. Cipriano, S. Pasternak, S.N. Whitehead* and A.R. Khan*. Post-mortem 7 Tesla MRI detection of white matter hyperintensities:  A multidisciplinary voxel-wise comparison of imaging and histological correlates. Neuroimage Clin. 2020;27:102340. doi: 10.1016/j.nicl.2020.102340. Epub 2020 Jul 6.* Both authors contributed equally.
  • A.D. Roseborough, V. Hachinski and S.N. Whitehead. White matter degeneration – a treatable target? JAMA Neurol. 2020 Apr 27
  • A. Levit, S. Cheng, O. Hough, Y. Agca, C. Agca, V. Hachinski and S.N. Whitehead. Hypertension and pathogenic hAPP independently induce white matter astrocytosis and cognitive impairment in the rat. Front Aging Neurosci. 2020 Apr 15;12:82.
  • M. Frietas-Andrade, J. Bechberger, J.S.H Wang, K.K.C Yeung, S.N. Whitehead, R.S Hansen, C.C. Naus. Danegaptide enhances astrocyte gap junction al coupling and reduces ischemic reperfusion brain injury in mice. Biomolecules. 2020 Feb 26;10(3):353
  • W.X. Wang and S.N. Whitehead. Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain.  Analyst. 2020 Apr 7;145(7):2473-2481.
  • A. Levit, V. Hachinski and S.N. Whitehead. Executive dysfunction, white matter pathology, and neurovascular unit dysregulation: the shared triad of vascular cognitive impairment and Alzheimer’s disease.  Geroscience. 2020 Apr;42(2):445-465.
  • A. Harris, A. Roseborough, R. Mor, K.K.C. Yeung and S.N. Whitehead. Ganglioside detection from formalin fixed human brain tissue utilizing MALDI imaging mass spectrometry. J Am Soc Mass Spectrom. 2020 Mar 4;31(3):479-487.
  • N. Ivanova, Q. Liu, C. Agca, Y. Agca, E.G. Noble, S.N. Whitehead and D.F. Cechetto. White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model. J Neuroinflammation. 2020 Jan 21;17(1):29

2019

  • F. Sorond, S.N. Whitehead, K. Arai, D. Arnold, S.T. Carmichael, C. De Carli, M. Duering, M. Fornage, R.E. Flores-Obando, J. Graff-Radford, E. Hamel, D.C. Hess, M. Ihara, M.K. Jensen, H.S. Markus, A. Montagne, G. Rosenberg, A.Y. Shih, E. E. Smith, A. Thiel, K.H. Tse, D. Wilcock and F. Barone. Proceedings for the Albert Charitable Trust inaugural workshop on white matter and cognition in aging. Accepted, GeroScience – Journal of the American Aging Association, 2019.
  • A. Harris, A. Roseborough, R. Mor, K.K.C. Yeung and S.N. Whitehead. Ganglioside detection from formalin fixed human brain tissue utilizing MALDI imaging mass spectrometry. Accepted, J Am Soc Mass Spectrom. 2019.
  • N. Ivanova, C. Agca, Y. Agca, E.G. Noble, S.N. Whitehead and D.F. Cechetto. Comorbidity of Alzheimer’s disease and metabolic syndrome in the APP21 transgenic rat. Accepted, Journal of Neuroinflammation, 2019.
  • V. Hachinski, K. Einhaupl, D. Ganten, S. Alladi, C. Brayne, B.C.M. Stephan, Z. Khachaturian, M. Sweeney, B. Zlokovic, Y. Iturria-Medina, C. Iadecola, N. Nishimura, C.B. Schaffer, S.N. Whitehead, S.E. Black, L. Ostergaard, J. Wardlaw, S. Greenberg, L. Friberg, B. Norrving, B. Rowe, Y. Joanette, W. Hacke, L. Kuller, M. Dichgans and M. Endres. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. Int J Stroke. 2019 Sep 22
  • V.M. Jaremek, S.N. Whitehead and L.A. Sposato. Lateralization of the control of cardiovascular autonomic function and left atrial injury after selective right and left insular stroke.  Int J Cardiol. 2019.
  • V. Hachinski, K. Einhaupl, D. Ganten, S. Alladi, C. Brayne, B.C.M. Stephan, Z. Khachaturian, M. Sweeney, B. Zlokovic, Y. Iturria-Medina, C. Iadecola, N. Nishimura, C.B. Schaffer, S.N. Whitehead, S.E. Black, L. Ostergaard, J. Wardlaw, S. Greenberg, L. Friberg, B. Norrving, B. Rowe, Y. Joanette, W. Hacke, L. Kuller, M. Dichgans and M. Endres. Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimers Dement. 2019 Jul;15(7):961-984.
  • B. Balint*, V. Jaremek*, V. Thorburn, M. Paquet, S.N. Whitehead* and L.A. Sposato*. Left atrial endothelial dysfunction, inflammation and fibrosis induced by selective insular cortex ischemic stroke in rats. Int J Cardiol. 2019 Jun 2. * Both authors contributed equally.
  • B. Halvorsron, S.N. Whitehead, J. McGuire, R. Wiseman, and J. Frisbee. Endothelium-dependent impairments to cerebral vascular reactivity with type-II diabetes mellitus in the Goto-Kakizaki rat.  Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R149-R159
  • A. Levit, A.M. Regis, A. Gibson, O.H. Hough, S. Maheshawari, Y. Agca, C. Agca, V. Hachinski, B.L. Allman and S.N. Whitehead. Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease. Brain Behav Immun. 2019 Feb 15.
  • C. Caughlin, J. Hepburn, Q. Liu, L. Wang, K.K.C Yeung, D.F. Cechetto and S.N. Whitehead. Chloroquine restores ganglioside homeostasis and improves pathological and behavioural outcomes post-stroke in the rat. Mol Neurobiol. 2019 May;56(5):3552-3562.

2018

  • N. Weishaupt*, Q. Liu*, S. Shin, R. Singh, Y. Agca, C. Agca, V. Hachinski and S.N. Whitehead. APP21transgenic rats develop age-dependent cognitive impairment and microglia within white matter tracts. J Neuroinflammation. 2018 Aug 28;15(1):241. * Both authors contributed equally.
  • L.A. Sposato, S. Fridman, S.N. Whitehead and R.D. Lopes. Linking stroke-induced heart injury and neurogenic atrial fibrillation: a hypothesis to be proven.  J Electrocardiol. 2018 Feb 20.
  • J.S.H Wang, M.F. Andrade, J. Bechberger, C. Naus, K.K.C. Yeung and S.N. Whitehead. MALDI-IMS of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke-reperfusion injury in the mouse. Rapid Commun Mass Spectrom. 2018 Jun 30;32(12):951-958.
  • S. Caughlin, S. Maheshwari, Y. Agca, C. Agca, K.K.C. Yeung, D.F. Cechetto and S.N. Whitehead. Membrane-lipid homeostasis in a prodromal rat model of AD: Characteristic shifts in ganglioside abundance during aging detected using MALDI imaging mass spectrometry.  Biochim Biophys Acta. 2018 Mar 13;1862(6):1327-1338.
  • J.S.H. Wang, S.N. Whitehead* and K.K.C. Yeung*. Detection of amyloid beta oligomeric composition using matrix assisted laser desorption ionization mass spectrometry. J Am Soc Mass Spectrom. 2018 Apr;29(4):786-795. * Both authors contributed equally.
  • J.R. Plemel, N.J. Michaels, N. Weishaupt, A.V. Caprariello, M.B. Keough, J.A Rogers, A. Yuseloglu, J. Lim, V.V. Patel, K.S. Rawji, S.K. Jensen, W. Teo, B. Heyne, S.N. Whitehead, P.K. Stys and V.W. Yong. Mechanisms of lysophosphatidylcholine-induced demyelination: a primary lipid disrupting myelinopathy. Glia. 2018 Feb;66(2):327-347.

2017

  • H. Ibrahim, K. Jurcic, J.S. Wang, S.N. Whitehead and K.K. Yeung. 1,6-Diphenyl-1,3,5-hexatriene (DPH) as a novel matrix for MALDI MS imaging of fatty acids, phospholipids and sulfatides in brain tissues. Anal Chem. 2017 Dec 5;89(23):12828-12836.
  • M. Paquet, J.O. Cerasuolo, V. Thorburn, S. Fridman, R. Alsubaie, R.D. Lopes, L.E. Cipriano, P. Salamone, C. W. James Melling, A.R. Khan, L. Sedeño, J. Fang, M. Drangova, M. Montero-Odasso, J. Mandzia, A.V. Khaw, J.M. Racosta, M.J. Paturel, L. Samoilov, D. Stirling, B. BalintV. Jaremek, M.L. Koschinsky, M.B. Boffa, K. Summers, A. Ibañez, M. Mrkobrada, G. Saposnik, K. Kimpinski, S.N. Whitehead, and L.A. Sposato. The pathophysiology and risk of atrial fibrillation detected after ischemic stroke (PARADISE) study: A translational, integrated and transdisciplinary approach. J Stroke Cerebrovasc Dis. 2018 Mar;27(3):606-619.
  • S. Caughlin, S. Maheshwari, N. Weishaupt, K.K.C. Yeung, D.F. Cechetto and S.N. Whitehead. Age-dependent and regional heterogeneity in the long-chain base of A-series gangliosides observed in the rat brain using MALDI imaging. Sci Rep. 2017 Nov 23;7(1):16135.
  • A. Levit*, A.M. Regis*, J.R. Garabon, O. Seung, S.H. Desai, N. Rajakumar, V. Hachinski, Y. Agca, C. Agca, S.N. Whitehead* and B.L. Allman*. Novel analyses of behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression. Behav Brain Res. 2017 Aug 30; 333:267-275. * Both authors contributed equally.
  • S. Caughlin, D.H Park, K.K.C Yeung, D.F. Cechetto and S.N. Whitehead. Sublimation of DAN matrix for the detection and visualization of gangliosides in rat brain tissue for MALDI imaging mass spectrometry.  J Vis Exp. 2017 Mar 23;(121).
  • L.A. Sposato, E.R. Vargas, P.M Riccio, J.B. Toledo, J.Q. Trojanowski, W.A. Kukull, L.E. Cipriano, A. Nucera, S.N. Whitehead and V.C. Hachinksi. Milder Alzheimer’s disease pathology in heart failure and atrial fibrillation. Alzheimer’s and Dementia, 2017 Jul;13(7):770-777
  • H.J. Nell, J.L. Au, C.R. Giordano, S.R. Terlecky, P.A. Walton, S.N. Whitehead and D.F. Cechetto. The targeted antioxidant, catalase-SKL, reduces beta-amyloid toxicity in the rat brain. Brain Pathol. 2017 Jan;27(1):86-94.

2016

  • S. Wong, D.F. Cechetto and S.N. Whitehead. Assessing the effects of acute amyloid beta oligomer exposure in the rat. Int. J. Mol. Sci. 2016, 17(9), 1390
  • H. Park, L. Wang, P. Pittock, G.A. Lajoie and S.N. Whitehead. Increased expression of GM1 detected by electrospray mass spectrometry in rat primary embryonic cortical neurons exposed to glutamate toxicity. Anal Chem. 2016 Aug 2;88(15):7844-52
  • H. Deibel*, N. Weishaupt*, A.M. Regis, N S. Hong, R.J. Keeley, RJ. Balog, C.M. Bye, S.M Himmler, S.N. Whitehead* and R. J. McDonald*. Subtle learning and momery impairment in an idiopathic rat model of Alzheimer’s disease utilizing cholinergic depletions and beta-amyloid. Brain Res. 2016 Sep 1;1646:12-24.* Authors contributed equally.
  • L. Au, N. Weishaupt, H.J. Nell, S.N. Whitehead and D.F Cechetto. Motor assessment and hippocampal dependent spatial learning and reference assessment in a transgenic rat model of Alzheimer’s disease with stroke.  J Vis Exp. 2016 Mar 22;(109)
  • Weishaupt, A. Zhang, R. Deziel, A. Tasker and S.N. Whitehead. Prefrontal ischemia in the rat leads to secondary damage and inflammation in remote grey and white matter regions. Front Neurosci. 2016 Mar 2;10:8
  • Xu, F. Bihari, S.N. Whitehead, E. Wong, S. Schmid and M.O. Hebb. Intratumoral modulation therapy induces apoptosis and facilitates temozolomide and gene therapy in glioblastoma. Anticancer Res. 2016 Jan; 36(1):71-

2015

  • WeishauptS. Caughlin, K.K.C. Yeung and S.N. Whitehead. Differential anatomical expression of ganglioside GM1 species containing d18:1 or d20:1 sphingosine detected by MALDI Imaging Mass Spectrometry in mature rat brain. Front Neuroanat. 2015 Dec 1;9:155.
  • Weishaupt, P. Riccio, T. Dobbs, V.C. Hachinski and S.N. Whitehead. Characterization of behaviour and remote degenerative processes following thalamic stroke. Int J Mol Sci. 2015 Jun 17;16(6):13921-36.
  • CaughlinJ. HepburnD.H. Park, K. Jurcic, K. Yeung, D.F. Cechetto and S.N. Whitehead. Increased expression of simple gangliosides species GM2 and GM3 detected by MALDI imaging mass spectrometry in a combined rat model of Abeta toxicity and stroke. PLoS One. 2015 Jun 18;10(6):e0130364.
  • Amtul, S.N. Whitehead, R. Keeley, J. Bechberger, A. Fisher, R. McDonald, C. Naus, D. Munoz and D.F. Cechetto. Co-morbid rat model of ischemia and beta-amyloid toxicity: Striatal and cortical degeneration. Brain Pathol. 2015 Jan;25(1):24-32.

2010 - 2014

  • H.J. Nell, S.N. Whitehead and D.F. Cechetto. Age dependent effect of β-amyloid toxicity on basal forebrain cholinergic neurons and inflammation in the rat brain. Brain Pathol. 2014 Sep 3.
  • A. Thiel, D.F. Cechetto, V.C Hachinski and S.N. Whitehead.  Amyloid burden, neuroinflammation and links to post-stroke cognitive impairment. Stroke. 2014 Sep;45(9):2825-9.
  • S. Gangaraju, K. Sultan, S.N Whitehead, L Nilchi, J. Slinn, X. Li, and S.T Hou. Cerebral endothelial expression of Robo1 affects brain infiltration of  polymorphonuclear neutrophils during mouse stroke recovery.  Neurobiol Dis. 2013 Mar 5;54C:24-31
  • P. Soros, S.N. Whitehead, J.D. Spence and V.C. Hachinski.  Antihypertensive treatment can prevent stroke and cognitive decline.  Nat Rev Neurol. 2013 Mar;9(3):174-8.
  • S.N. Whitehead, S. Gangaraju, A. Aylsworth and S.T. Hou.  Membrane raft disruption results in neuritic retraction prior to neuronal death in cortical neurons. Biosci Trends. 2012 Aug;6(4):183-91
  • S.N. Whitehead, K.H.N Chan, S. Gangaraju, J. Slinn, J. Li and S.T. Hou.  Imaging Mass Spectrometry Detection of Gangliosides Species Within the Mouse Brain Following Transient Focal Cerebral Ischemia. PLoS One. 2011;6(6):e20808. Epub 2011 Jun 8
  • S.N. Whitehead, E. Massoni, G. Cheng, V. Hachinski, M. Cimino, W. Balduini and D. F. Cechetto.  Brain Res. 2010 Dec 17;1366:246-56. Epub 2010 Oct 8.
  • S.N. Whitehead, S. Gangaraju, J. Slinn and S.T. Hou.  Transient and bilateral increase in Neuropilin-1, Fer kinase and collapsin response mediator proteins within membrane rafts following unilateral occlusion of the middle cerebral artery in mouse. Brain Res. 2010 Jul 16;1344:209-16.
  • S.X. Jiang, S.N. Whitehead, A. Aylsworth, J. Slinn, B. Zurakouski, K. Chan, J. Li and S.T. Hou. Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin3A-induced death of cortical neurons. J Biol Chem. 2010 Mar 26;285(13):9908-18
  • M.A. Cortex, C. Li, S.N. Whitehead, L.J. Huan, S.A.L Bennett, C. Snead and C.E. Bear.  Disruption of CLC-2 expression leads to neurodegeneration in aging mice. Neuroscience. 2010 Apr 28;167(1):154-62

2005 - 2009

  • S.D Ryan, S.N. Whitehead, W. Hou, L. Swayne, M. Ethier, A.J.G Bourgeois, T.C. Moffat, J. Rashidian J, D. Qu, P.E. Fraser, D. Figeys, D.S. Park and S.A.L. Bennett. Aberrant lipid metabolism compromises neuronal vulnerability in Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Nov 19.
  • J.C. Smith, W. Hou, S.N. Whitehead, M. Ethier, S.A.L. Bennett and D. Figeys.  Real-time sequencing of glycerophospholipids in vitro and in vivo using LC-MS3.  Rapid Comm. In Rapid Commun Mass Spectrom. 2008 Nov;22(22):3579-87.
  • D.F. Cechetto, V.C. Hachinski and S.N. Whitehead. Vascular risk factors and Alzheimer’s disease. Expert Rev Neurother. 2008 May;8(5):743-50.
  • S. Wislet-Gendebien, N. Visanji, S.N. Whitehead, D. Marsilio, W. Hou, D. Figeys, P.E. Fraser, S.A.L. Bennett, and A. Tandon. Differential regulation of wild-type and mutant α-synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci. 2008 Sep 22;9:92
  • S.N. Whitehead, G. Cheng, V. Hachinski and D.F. Cechetto. Progressive increase in infarct size, neuroinflammation and cognitive deficits in the presence of high levels of amyloid. Stroke. 2007 Dec;38(12):3245-50.
  • S.N. Whitehead, W. Hou, M. Ethier, J. Smith, R. Denis, S.A.L. Bennett and D. Figeys. Rapid identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high performance liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem. Nov 2007 15;79(22):8539-48.
  • S.R. Vlahakis, S.A. Bennett, S.N. Whitehead and A.D. Badley. HIV protease inhibitors modulate apoptosis signalling in vitro and in vivo. Apoptosis. 2007 May;12(5):969-77
  • S.N. Whitehead, N.A. Bayona, G. Cheng, G. Allen, V. Hachinski and D.F. Cechetto. Effects of triflusal and aspirin in a rat model of cerebral ischemia. Stroke. 2007 Feb;38(2):381-7.
  • S.N. Whitehead, N.A. Bayona, G. Cheng, G. Allen, V. Hachinski and D.F. Cechetto. Effects of triflusal and aspirin in a rat model of cerebral ischemia. Stroke. 2007 Feb;38(2):381-7.
  • G. Cheng, S.N. Whitehead, V. Hachinski and D.F.Cechetto. Effects of pyrrolidine dithiocarbamate on beta-amyloid (25-35)-induced inflammatory responses and memory deficits in the rat. Neurobiol Dis. 2006 Jul;23(1):140-51
  • S.N. Whitehead, V. Hachinksi, G Cheng and D.F. Cechetto.  Interaction between a rat model of Ab toxicity and cerebral ischemia:  Ii.Effects of triflusal, a Cox-2 inhibitor. Stroke 2005; 36(8):1782-9.
  • S.N. Whitehead, V. Hachinksi and D.F. Cechetto.  Interaction between a rat model of Ab toxicity and cerebral ischemia:  I. Inflammatory Responses. Stroke 2005; 36(1):107-12